A 770041
Axon 1698
CAS [869748-10-7]
MF C34H39N9O3MW 621.73
- Purity:99%
- Soluble in DMSO
Description
Selective and orally active Src-family Lck inhibitor; A-770041 is a 147 nM inhibitor of Lck (1 mM ATP) and is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling.
Keywords: A 770041 | supplier | Lck inhibitor | A770041 | A-770041 | CAS [869748-10-7] | Non Selective (Phosphorylation Substrates) | Lck | Inhibitor | Enzymes
| RF tachlewitz et al. A-770041, a novel and selective small-molecule inhibitor of Lck, prevents heart allograft rejection. J Pharmacol Exp Ther. 2005 Oct;315(1):36-41. |
List of publications using A 770041 (Axon 1698) purchased from Axon Medchem
- Certificate of Analysis
- Material Safety Data Sheet
Chemical name
N-(4-(1-(4-(4-acetylpiperazin-1-yl)cyclohexyl)-4-amino-1H-pyrazolo[3,4-d]pyrimidin-3-yl)-2-methoxyphenyl)-1-methyl-1H-indole-2-carboxamide
Parent CAS No.
[869748-10-7]
Axon Medchem的业务之一，是独有的Axon Ligands配体库，在世界范围内，被认为是药物研发的标准。这其中，针对850余种生物靶标（包括细胞信号、基因转录、凋亡、细胞周期调控、CNS等），Axon Medchem拥有多达2000余种小分子抑制剂或调节剂。除了配体库，Axon Medchem还是欧洲著名的CRO公司，主要针对生物活性分子和药物类似分子展开合成及协议开发工作，在过去的10年中，Axon Medchem已经发现了多种潜在药物分子，并在生物医药界享有一定的声誉。
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