AC 264613
Axon 2898
CAS [1051487-82-1]
MF C19H18BrN3O2MW 400.27
- Purity:98%
- Soluble in DMSO
Description
AC 264613 is a potent, selective, and metabolically stable protease activated receptor 2 (PAR2) agonist (pEC50 value of 6.7). The potency of AC 264613 in the cellular proliferation assay was approximately 50 nM, and was virtually the same at wild-type PAR2 receptors. Incubation of macrophages with AC 264613 caused a decrease of IRF5 expression and also significantly reduced p53 protein expression.
KEYWORDS: AC 264613 | supplier | PAR2 agonist | AC-264613 | AC264613 | CAS [1051487-82-1] | Thrombin | Thrombin (PAR) | Agonist | Receptors
| JG Seitzberg et al. Discovery of potent and selective small-molecule PAR-2 agonists. J Med Chem. 2008 Sep 25;51(18):5490-3. |
| LR Gardell et al. Identification and characterization of novel small-molecule protease-activated receptor 2 agonists. J Pharmacol Exp Ther. 2008 Dec;327(3):799-808. |
| R Yamaguchi et al. A protease-activated receptor 2 agonist (AC-264613) suppresses interferon regulatory factor 5 and decreases interleukin-12p40 production by lipopolysaccharide-stimulated macrophages: Role of p53. Cell Biol Int. 2016 Jun;40(6):629-41. |
- Certificate of Analysis
- Material Safety Data Sheet
Chemical name
N"-(1-(3-Bromophenyl)ethylidene)-2-oxo-4-phenylpyrrolidine-3-carbohydrazide
Parent CAS No.
[1051487-82-1]
Axon Medchem的业务之一，是独有的Axon Ligands配体库，在世界范围内，被认为是药物研发的标准。这其中，针对850余种生物靶标（包括细胞信号、基因转录、凋亡、细胞周期调控、CNS等），Axon Medchem拥有多达2000余种小分子抑制剂或调节剂。除了配体库，Axon Medchem还是欧洲著名的CRO公司，主要针对生物活性分子和药物类似分子展开合成及协议开发工作，在过去的10年中，Axon Medchem已经发现了多种潜在药物分子，并在生物医药界享有一定的声誉。
暂无问答
本网站将在规定时间内给予删除等相关处理。
