AVE 0118 hydrochloride

Based on 8 reference(s) in Google Scholar9108

Axon 2243

CAS [498577-53-0 (parent)]

MF C30H29N3O3.HClMW 516.03

Purity:99%
Soluble in water and DMSO

AVE 0118 hydrochloride

Description

Potassium channel blocker. AVE0118 caused concentration-dependent inhibition of Kv1.5 (IKur), Kv4.3 (Ito),Kir3.4 (IKAch), and IKr currents (IC50 values 6.2 μM,3.4 μM, 4.5 μM, and 10 μM resp.). A potent and atrium selective antiarrhythmic compound with no apparent effect on ventricular repolarization. Noteworthy, the atrial selective and dose-dependent prolongation of atrial refractoriness (ERP) by AVE 0118 has been claimed to be an inhibitory effect of sodium channel activity in an atrial-selective manner, and may therefor contribute to anti-AF properties of AVE0118.

References
Certificates
Categories
Extra info

H. Gögelein et al. Effects of the atrial antiarrhythmic drug AVE0118 on cardiac ion channels. Naun. Schmiedebergs Arch. Pharmacol. 2004, 370, 183-192.

K.J. Wirth et al. Atrial effects of the novel K+-channel-blocker AVE0118 in anesthetized pigs. Cardiovascular Res. 2003, 60, 298-306.

A. Burashnikov et al. Atrial-selective prolongation of refractory period with AVE0118 is due principally to inhibition of sodium channel activity. J. Cardiovasc. Pharmacol. 2012, 59, 539-546.

Certificate of Analysis
Material Safety Data Sheet

CardiovascularCell Signaling & OncologyCNSDiabetes & MetabolismPain & InflammationKv1.5Kv4.3Kir4.3KCND3KCNJ5KCNE1

Potassium channel blocker (Kv1.5 (IKur), Kv4.3 (Ito),Kir3.4 (IKAch), and IKr currents)

Chemical name

2"-((2-(4-methoxyphenyl)acetamido)methyl)-N-(2-(pyridin-3-yl)ethyl)biphenyl-2-carboxamide hydrochloride

Parent CAS No.

[498577-53-0]

品牌介绍

Axon Medchem的业务之一，是独有的Axon Ligands配体库，在世界范围内，被认为是药物研发的标准。这其中，针对850余种生物靶标（包括细胞信号、基因转录、凋亡、细胞周期调控、CNS等），Axon Medchem拥有多达2000余种小分子抑制剂或调节剂。除了配体库，Axon Medchem还是欧洲著名的CRO公司，主要针对生物活性分子和药物类似分子展开合成及协议开发工作，在过去的10年中，Axon Medchem已经发现了多种潜在药物分子，并在生物医药界享有一定的声誉。

公司介绍

更多...

产品分类

更多...

Enzymes Biomarkers & Labeling reagents Receptors Transcription Factors Assorted Products Axon Ligand™ Sets Ion Channels Proteins

销售排行

更多...