CP 31398
Axon 2879
CAS [1217195-61-3]
MF C22H28Cl2N4OMW 435.39
- Purity:98%
- Soluble in water and DMSO
Description
CP 31398 stabilizes the core domain of the tumour suppressor p53 in vitro and is an effective anti-cancer drug by virtue of rescuing destabilized mutants of p53. Moreover, CP 31398 can induce apoptosis of human cancer cells.
KEYWORDS: CP 31398 | supplier | p53 stabilizer | CP31398 | CP-31398 | CAS [1217195-61-3] | [259199-65-0] | Non Selective | p53 | Stabilizer | Transcription Factors | Apoptosis
| BA Foster et al. Pharmacological rescue of mutant p53 conformation and function. Science. 1999 Dec 24;286(5449):2507-10. |
| TM Rippin et al. Characterization of the p53-rescue drug CP-31398 in vitro and in living cells. Oncogene. 2002 Mar 28;21(14):2119-29. |
| R Takimoto et al. The mutant p53-conformation modifying drug, CP-31398, can induce apoptosis of human cancer cells and can stabilize wild-type p53 protein. Cancer Biol Ther. 2002 Jan-Feb;1(1):47-55. |
- Certificate of Analysis
- Material Safety Data Sheet
Chemical name
(E)-N1-(2-(4-methoxystyryl)quinazolin-4-yl)-N3,N3-dimethylpropane-1,3-diamine dihydrochloride
Parent CAS No.
[259199-65-0]
Axon Medchem的业务之一，是独有的Axon Ligands配体库，在世界范围内，被认为是药物研发的标准。这其中，针对850余种生物靶标（包括细胞信号、基因转录、凋亡、细胞周期调控、CNS等），Axon Medchem拥有多达2000余种小分子抑制剂或调节剂。除了配体库，Axon Medchem还是欧洲著名的CRO公司，主要针对生物活性分子和药物类似分子展开合成及协议开发工作，在过去的10年中，Axon Medchem已经发现了多种潜在药物分子，并在生物医药界享有一定的声誉。
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