(R)-CE3F4
Axon 2830
CAS [1593478-56-8]
MF C11H10Br2FNOMW 351.01
- Purity:99%
- Optical purity:98% e.e.
- Soluble in DMSO
Description
(R)-CE3F4 is an inhibitor of EPAC1 (IC50 value of 5.8 µM) with a 10-fold selectivity for EPAC1 over EPAC2. (R)-CE3F4 prevents EPAC1 activation in vitro and in living cultured cells by inhibiting the GEF activity of EPAC1. Racemic CE3F4 is available as Axon 2929.
KEYWORDS: (R)-CE3F4 | supplier | EPAC1 inhibitor | CAS [1593478-56-8] | cAMP | EPAC | Inhibitor | Proteins
| D Courilleau et al. The (R)-enantiomer of CE3F4 is a preferential inhibitor of human exchange protein directly activated by cyclic AMP isoform 1 (Epac1). Biochem Biophys Res Commun. 2013 Oct 25;440(3):443-8. |
- Certificate of Analysis
- Material Safety Data Sheet
Chemical name
(R)-5,7-Dibromo-6-fluoro-2-methyl-3,4-dihydroquinoline-1(2H)-carbaldehyde
Parent CAS No.
[1593478-56-8]
Axon Medchem的业务之一，是独有的Axon Ligands配体库，在世界范围内，被认为是药物研发的标准。这其中，针对850余种生物靶标（包括细胞信号、基因转录、凋亡、细胞周期调控、CNS等），Axon Medchem拥有多达2000余种小分子抑制剂或调节剂。除了配体库，Axon Medchem还是欧洲著名的CRO公司，主要针对生物活性分子和药物类似分子展开合成及协议开发工作，在过去的10年中，Axon Medchem已经发现了多种潜在药物分子，并在生物医药界享有一定的声誉。
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