Barbadin
Axon 2774
CAS [356568-70-2]
MF C19H15N3OSMW 333.41
- Purity:99%
- Soluble in DMSO
Description
Selective β-arrestin/β2-adaptin interaction inhibitor (IC50 values of 19.1 and 15.6 μM for β-arrestin1 and β-arrestin2, respectively). Barbadin blocks agonist-promoted endocytosis of the prototypical β2-adrenergic, V2-vasopressin and angiotensin-II type-1 receptors, but does not affect β-arrestin-independent (transferrin) or AP2-independent (endothelin-A) receptor internalization.
KEYWORDS: Barbadin | supplier | β-Arrestin/β2-Adaptin inhibitor | CAS [356568-70-2] | AP2 | β-Arrestin | Inhibitor | Proteins | GPCR | β2-Adrenergic | V2-Vasopressin | Angiotensin-II type-1 | Transferrin | Endothelin-A
| A Beautrait et al. A new inhibitor of the β-arrestin/AP2 endocytic complex reveals interplay between GPCR internalization and signalling. Nat Commun. 2017 Apr 18;8:15054. |
- Certificate of Analysis
- Material Safety Data Sheet
Chemical name
3-Amino-5-(4-benzylphenyl)thieno[2,3-d]pyrimidin-4(3H)-one
Parent CAS No.
[356568-70-2]
Axon Medchem的业务之一，是独有的Axon Ligands配体库，在世界范围内，被认为是药物研发的标准。这其中，针对850余种生物靶标（包括细胞信号、基因转录、凋亡、细胞周期调控、CNS等），Axon Medchem拥有多达2000余种小分子抑制剂或调节剂。除了配体库，Axon Medchem还是欧洲著名的CRO公司，主要针对生物活性分子和药物类似分子展开合成及协议开发工作，在过去的10年中，Axon Medchem已经发现了多种潜在药物分子，并在生物医药界享有一定的声誉。
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