Stem Cell 5i inhibitor Set
Axon 5007
CAS [N.A.]
MF #N/AMW #N/A
- Purity:99%
- Soluble in DMSO
Description
A convenient set of five small molecule pathway inhibitors, BMP inhibitor LDN 193189 hydrochloride (Axon 1509), TGF-beta inhibitor SB 431542 (Axon 1661) and GSK3 inhibitor CHIR 99021 (Axon 1386), FGFR inhibitor SU 5402 (Axon 1667) and Gamma secretase inhibitor DAPT (Axon 1484) (termed as stem cell 5i or LSB3i or LSB+3i inhibitor set), for neural differentiation of human pluripotent stem cells (hPSCs). Stem Cell 5i (or LSB3i) inhibitor cocktail protocol, actually a combination of LSB inhibitor set (Axon 5004) and neuronal 3i (CSD) inhibitor set (Axon 5006), was used for rapid and efficient differentiateing hPSCs into nociceptors.
Read more: Additional Product Information
Show all Axon Ligand™Sets
| S.M. Chambers et al. Combined small-molecule inhibition accelerates developmental timing and converts human pluripotent stem cells into nociceptors. Nature Biotechnol. 2012, 30, 715-720. |
List of publications using LDN 193189 hydrochloride (Axon 1509) purchased from Axon Medchem
List of publications using CHIR 99021 (Axon 1386) purchased from Axon Medchem
- Certificate of Analysis
- Material Safety Data Sheet
- Additional Product Information
Chemical name
N.A.
Parent CAS No.
[N.A.]
Axon Medchem的业务之一，是独有的Axon Ligands配体库，在世界范围内，被认为是药物研发的标准。这其中，针对850余种生物靶标（包括细胞信号、基因转录、凋亡、细胞周期调控、CNS等），Axon Medchem拥有多达2000余种小分子抑制剂或调节剂。除了配体库，Axon Medchem还是欧洲著名的CRO公司，主要针对生物活性分子和药物类似分子展开合成及协议开发工作，在过去的10年中，Axon Medchem已经发现了多种潜在药物分子，并在生物医药界享有一定的声誉。
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