15-LOX-1 inhibitor i472
Axon 2989
CAS [N.A.]
MF C22H21ClN2O4MW 412.87
- Purity:98%
- Soluble in DMSO
Description
Inhibitor of 15-lipoxygenase-1 (15-LOX-1) with an IC50 value of 0.19 μM. 15-LOX-1 inhibitor i472 shows an ability to protect RAW 264.7 macrophages from LPS-induced cell death. Furthermore, i472 is shown to provide significant inhibition of NF-κB transcriptional activation upon LPS/INFγ stimulation, to downregulate the expression of the NF-κB related gene iNOS, to provide dose-dependent inhibition of NO production and to reduce lipid peroxidation in RAW macrophages.*Sold in collaboration with RuG (University of Groningen)
KEYWORDS: 15-LOX-1 inhibitor i472 | supplier | Lipoxygenase inhibitor | 15-LOX-1 inhibitor i 472 | 15-LOX-1 inhibitor i-472 | CAS [N.A.] | Fatty acid (Arachidonic acid) | LOX | Inhibitor | Enzymes
| H Guo et al. Novel 15-Lipoxygenase-1 Inhibitor Protects Macrophages from Lipopolysaccharide-Induced Cytotoxicity. J Med Chem. 2019 May 9;62(9):4624-4637. |
- Certificate of Analysis
- Material Safety Data Sheet
Chemical name
(E)-Ethyl 6-chloro-3-(3-(2-methoxybenzylamino)-3-oxoprop-1-enyl)-1H-indole-2-carboxylate
Source information
Sold in collaboration with RuG (University of Groningen)Parent CAS No.
[N.A.]
Axon Medchem的业务之一，是独有的Axon Ligands配体库，在世界范围内，被认为是药物研发的标准。这其中，针对850余种生物靶标（包括细胞信号、基因转录、凋亡、细胞周期调控、CNS等），Axon Medchem拥有多达2000余种小分子抑制剂或调节剂。除了配体库，Axon Medchem还是欧洲著名的CRO公司，主要针对生物活性分子和药物类似分子展开合成及协议开发工作，在过去的10年中，Axon Medchem已经发现了多种潜在药物分子，并在生物医药界享有一定的声誉。
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