Axon 3159
CAS [23828-92-4]
MF C13H18Br2N2O.HClMW 414.56
Ambroxol hydrochloride is an expectorant and mucokinetic compound. Ambroxol hydrochloride is shown to exert several activities: i) secretolytic activity ii) anti-inflammatory and antioxidant activity; and iii) a local anaesthetic effect through sodium channel blocking at the level of the cell membrane.
KEYWORDS: Ambroxol hydrochloride | supplier | Expectorant | CAS [23828-92-4] | [18683-91-5] | Free radical scavenger | Non Selective | Modulator
A Gillissen et al. Characterization of N-acetylcysteine and ambroxol in anti-oxidant therapy. Respir Med. 1998;92(4):609‐623. |
T Weiser et al. Inhibition of tetrodotoxin (TTX)-resistant and TTX-sensitive neuronal Na(+) channels by the secretolytic ambroxol. Mol Pharmacol. 2002;62(3):433‐438. |
M Malerba et al. Ambroxol in the 21st century: pharmacological and clinical update. Expert Opin Drug Metab Toxicol. 2008;4(8):1119-1129. |
trans-4-(2-Amino-3,5-dibromobenzylamino)cyclohexanol hydrochloride
[18683-91-5]
Axon Medchem的业务之一,是独有的Axon Ligands配体库,在世界范围内,被认为是药物研发的标准。这其中,针对850余种生物靶标(包括细胞信号、基因转录、凋亡、细胞周期调控、CNS等),Axon Medchem拥有多达2000余种小分子抑制剂或调节剂。除了配体库,Axon Medchem还是欧洲著名的CRO公司,主要针对生物活性分子和药物类似分子展开合成及协议开发工作,在过去的10年中,Axon Medchem已经发现了多种潜在药物分子,并在生物医药界享有一定的声誉。