Dansyl-PEG-phenylboronic acid
Axon 2257
CAS [N.A.]
MF C30H41BN4O9SMW 644.54
- Purity:98%
- Soluble in 0.1N HCl(aq), MeOH and DMSO
Description
Dansylamide functionalized PEG-phenylboronic acid for the use of palladium-catalyzed oxidative Heck reaction to protein-bound alkenes and Suzuki-Miyaura cross coupling for labeling of protein bound phenylhalides in high yields and with excellent chemoselectivity. Reagent for bio-orthogonal protein-ligation.*Sold in collaboration with RuG (University of Groningen)
| ME Ourailidou et al. Aqueous oxidative Heck reaction as a protein-labeling strategy. Chembiochem. 2014, 15, 209-212. |
| F D"Hooge et al. Biotinylated boronic acid fluorophore conjugates: Quencher elimination strategy for imaging and saccharide detection. RSC Adv. 2012, 2, 3274-3280. |
| Chalker et al. A Convenient Catalyst for Aqueous and Protein Suzuki-Miyaura Cross-Coupling J. Am. Chem. Soc. 2009, 131, 16346-16347 |
| C.D. Spicer et al. Palladium-mediated site-selective Suzuki-Miyaura protein modification at genetically encoded aryl halides. Chem. Commun. 2011, 47, 1698-700 |
| C.D. Spicer et al. Palladium-mediated cell-surface labeling. J. Am. Chem. Soc. 2012, 134(2), 800-3. |
- Certificate of Analysis
- Material Safety Data Sheet
Chemical name
3-(1-(5-(dimethylamino)naphthalene-1-sulfonamido)-13-oxo-3,6,9-trioxa-12-azahexadecanamido)phenylboronic acid
Source information
Sold in collaboration with RuG (University of Groningen)Parent CAS No.
[N.A.]
Axon Medchem的业务之一，是独有的Axon Ligands配体库，在世界范围内，被认为是药物研发的标准。这其中，针对850余种生物靶标（包括细胞信号、基因转录、凋亡、细胞周期调控、CNS等），Axon Medchem拥有多达2000余种小分子抑制剂或调节剂。除了配体库，Axon Medchem还是欧洲著名的CRO公司，主要针对生物活性分子和药物类似分子展开合成及协议开发工作，在过去的10年中，Axon Medchem已经发现了多种潜在药物分子，并在生物医药界享有一定的声誉。
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