Naive Stem Cell 5i inhibitor Set
Axon 5011
CAS [N.A.]
MF #N/AMW #N/A
- Purity:99%
- Soluble in DMSO
Description
A convenient set of five small molecule pathway inhibitors (termed as Naive stem cell 5i inhibitors): - BRAF inhibitor SB 590885 (Axon 2504) - MEK inhibitor PD 0325901 (Axon 1408) - ROCK inhibitor Y 27632 dihydrochloride (Axon 1683) - SRC/LCK inhibitor WH 4-023 (Axon 2381) - GSK3β inhibitor IM-12 (Axon 2511).(*Alternatively, CHIR99021 (Axon 1386) can be used as GSK3β inhibitor. Not included.) The combination of five inhibitors of MEK, GSK3β, BRAF, ROCK, and SRC, supports the expansion of viable OCT4-ΔPE-GFP+ human pluripotent cells after exogenous transcription factor expression has been removed. Useful tool for the induction and maintenance of human naive stem cell pluripotency.
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KEYWORDS: Naive Stem Cell 5i inhibitor Set | supplier | Stem cell inhibitor set | SB 590885 | PD 0325901 | Y 27632 | WH-4-023 | IM 12 | CAS [405554-55-4] | [391210-10-9] | [129830-38-2] | [837422-57-8] | [1129669-05-1] | Inhibitor | Axon Ligand Sets | BRAF | MEK | ROCK | Src | Lck | GSK3β | naive | expansion | OCT4-ΔPE-GFP+ | pluripotent | hPCs | transcription factor | induction | human | stem cell | hPSC | pluripotency
| TW Theunissen et al. Systematic identification of culture conditions for induction and maintenance of naive human pluripotency. Cell Stem Cell. 2014 Oct 2;15(4):471-87. |
List of publications using PD 0325901 (Axon 1408) purchased from Axon Medchem
List of publications using Y 27632 dihydrochloride (Axon 1683) purchased from Axon Medchem
- Certificate of Analysis
- Material Safety Data Sheet
- Additional Product Information
Chemical name
N.A.
Parent CAS No.
[N.A.]
Axon Medchem的业务之一，是独有的Axon Ligands配体库，在世界范围内，被认为是药物研发的标准。这其中，针对850余种生物靶标（包括细胞信号、基因转录、凋亡、细胞周期调控、CNS等），Axon Medchem拥有多达2000余种小分子抑制剂或调节剂。除了配体库，Axon Medchem还是欧洲著名的CRO公司，主要针对生物活性分子和药物类似分子展开合成及协议开发工作，在过去的10年中，Axon Medchem已经发现了多种潜在药物分子，并在生物医药界享有一定的声誉。
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