A-196
Axon 2705
CAS [1982372-88-2]
MF C18H16Cl2N4MW 359.25
- Purity:99%
- Soluble in 0.1N HCl(aq) and DMSO
Description
A-196 is a potent and selective inhibitor of SUV420H1 and SUV420H2 ((IC50 values of 25 and 144 nM, respectively). In cells, A-196 induced a global decrease in H4K20me2 and H4K20me3 and a concomitant increase in H4K20me1. A-196 inhibited 53BP1 foci formation upon ionizing radiation and reduced NHEJ-mediated DNA-break repair but did not affect homology-directed repair.
KEYWORDS: A-196 | supplier | SUV4-20 inhibitor | A196 | A 196 | CAS [1982372-88-2] | Non Selective (Lysine Sites Proteins) | PKMT | Inhibitor | Enzymes | Protein Lysine Methyltransferase | Histone Methyltransferase | SUV420H1 | SUV420H2
| KD Bromberg et al. The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity. Nat Chem Biol. 2017 Mar;13(3):317-324. |
- Certificate of Analysis
- Material Safety Data Sheet
Chemical name
6,7-Dichloro-N-cyclopentyl-4-(pyridin-4-yl)phthalazin-1-amine
Parent CAS No.
[1982372-88-2]
Axon Medchem的业务之一，是独有的Axon Ligands配体库，在世界范围内，被认为是药物研发的标准。这其中，针对850余种生物靶标（包括细胞信号、基因转录、凋亡、细胞周期调控、CNS等），Axon Medchem拥有多达2000余种小分子抑制剂或调节剂。除了配体库，Axon Medchem还是欧洲著名的CRO公司，主要针对生物活性分子和药物类似分子展开合成及协议开发工作，在过去的10年中，Axon Medchem已经发现了多种潜在药物分子，并在生物医药界享有一定的声誉。
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