ABC294640 - Opaganib
Axon 2880
CAS [915385-81-8]
MF C23H25ClN2OMW 380.91
- Purity:98%
- Soluble in 0.1N HCl(aq) and DMSO
Description
ABC294640 is a selective and orally available Sphingosine kinase 2 inhibitor (SphK2 or SK2) in vitro, acting as a competitive inhibitor with respect to sphingosine with a Ki of 9.8 μM, and attenuates S1P formation in intact cells. In tissue culture, ABC294640 suppresses the proliferation of a broad panel of tumor cell lines, and inhibits tumor cell migration concomitant with loss of microfilaments. ABC294640 shows in vivo SK inhibitory activity in mice. Drug candidate for the treatment of cancer and other diseases.
KEYWORDS: ABC294640 | supplier | SphK2 inhibitor | Opaganib | ABC 294640 | ABC-294640 | CAS [915385-81-8] | [1185157-59-8] | Sphingosine | SphK | Inhibitor | Enzymes | Ulcerative colitis | Crohn’s Disease | Inflammatory bowel disease
| LW Maines et al. Suppression of ulcerative colitis in mice by orally available inhibitors of sphingosine kinase. Dig Dis Sci. 2008 Apr;53(4):997-1012. |
| KJ French et al. Pharmacology and antitumor activity of ABC294640, a selective inhibitor of sphingosine kinase-2. J Pharmacol Exp Ther. 2010 Apr;333(1):129-39. |
- Certificate of Analysis
- Material Safety Data Sheet
Chemical name
3-(4-Chlorophenyl)-N-(pyridin-4-ylmethyl)adamantane-1-carboxamide
Parent CAS No.
[915385-81-8]
Axon Medchem的业务之一，是独有的Axon Ligands配体库，在世界范围内，被认为是药物研发的标准。这其中，针对850余种生物靶标（包括细胞信号、基因转录、凋亡、细胞周期调控、CNS等），Axon Medchem拥有多达2000余种小分子抑制剂或调节剂。除了配体库，Axon Medchem还是欧洲著名的CRO公司，主要针对生物活性分子和药物类似分子展开合成及协议开发工作，在过去的10年中，Axon Medchem已经发现了多种潜在药物分子，并在生物医药界享有一定的声誉。
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