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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
axonmedchem/Abiraterone acetate                                                     - CB 7630 | JNJ 212082
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场      地:美国(厂家直采)
产品分类: 蛋白类>聚合物>
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美  元  价:$90.00
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axonmedchem/Abiraterone acetate                                                     - CB 7630 | JNJ 212082
商品介绍

Abiraterone acetate - CB 7630 | JNJ 212082

Based on 14 reference(s) in Google Scholar81014

Axon 1874

CAS [154229-18-2]

MF C26H33NO2MW 391.55

  • Purity:100%
  • Optical purity:Optically pure
  • Poorly soluble in DMSO

Abiraterone acetate

Description

Orally administered prodrug of Abiraterone (Axon 1873); inhibitor of the steroidal enzyme 17 α-hydroxylase/C17,20 lyase (CYP17A1); a drug used in castration-resistant prostate cancer (CRPC)

G Attard et al. Selective blockade of androgenic steroid synthesis by novel lyase inhibitors as a therapeutic strategy for treating metastatic prostate cancer. BJU Int. 2005, 96 (9), 1241–1246.
JE Ang et al. CYP17 blockade by abiraterone: further evidence for frequent continued hormone-dependence in castration-resistant prostate cancer. Br. J. Cancer 2009, 100(5), 671–675.
  • Certificate of Analysis
  • Material Safety Data Sheet
Cell Signaling & OncologyDiabetes & MetabolismEndocrinologyEC 1.14.99.9Cytochrome P450
Prodrug of Abiraterone; Inhibitor of CYP17A1

Chemical name

(3S,8R,9S,10R,13S,14S)-10,13-dimethyl-17-(pyridin-3-yl)-2,3,4,7,8,9,10,11,12,13,14,15-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl acetate

Parent CAS No.

[154229-18-2]

品牌介绍

Axon Medchem的业务之一,是独有的Axon Ligands配体库,在世界范围内,被认为是药物研发的标准。这其中,针对850余种生物靶标(包括细胞信号、基因转录、凋亡、细胞周期调控、CNS等),Axon Medchem拥有多达2000余种小分子抑制剂或调节剂。除了配体库,Axon Medchem还是欧洲著名的CRO公司,主要针对生物活性分子和药物类似分子展开合成及协议开发工作,在过去的10年中,Axon Medchem已经发现了多种潜在药物分子,并在生物医药界享有一定的声誉。

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