A2764 dihydrochloride - TRESK inhibitor A2764
Axon 3019
CAS [861038-72-4]
MF C15H19ClN2O.2HClMW 351.70
- Purity:99%
- Soluble in water and DMSO
Description
A2764 dihydrochloride is a selective inhibitor of TRESK (KCNK18) with an IC50 value of 11.8 μM. The degree of inhibition by 100 µM A2764 was larger in the activated state of TRESK than in the resting state of the channel. A2764 can inhibit TRESK in native cells, leading to cell depolarization and increased excitability.
KEYWORDS: A2764 dihydrochloride | supplier | TRESK inhibitor | A 2764 dihydrochloride | A-2764 dihydrochloride | CAS [861038-72-4] | [809248-52-0] | Potassium | TRESK | Inhibitor | Ion Channels | Migraine | Neuropathic pain | K2P18.1
| M Lengyel et al. Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K2P18.1) Background Potassium Channel. Mol Pharmacol. 2019 Jun;95(6):652-660. |
- Certificate of Analysis
- Material Safety Data Sheet
Chemical name
2-(5-Chloroquinolin-8-yloxy)-N,N-diethylethanamine dihydrochloride
Parent CAS No.
[809248-52-0]
Axon Medchem的业务之一，是独有的Axon Ligands配体库，在世界范围内，被认为是药物研发的标准。这其中，针对850余种生物靶标（包括细胞信号、基因转录、凋亡、细胞周期调控、CNS等），Axon Medchem拥有多达2000余种小分子抑制剂或调节剂。除了配体库，Axon Medchem还是欧洲著名的CRO公司，主要针对生物活性分子和药物类似分子展开合成及协议开发工作，在过去的10年中，Axon Medchem已经发现了多种潜在药物分子，并在生物医药界享有一定的声誉。
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