A2793
Axon 3060
CAS [88349-90-0]
MF C13H12ClNO3MW 265.69
- Purity:98%
- Soluble in DMSO
Description
A2793 is an inhibitor of TRESK (IC50 value of 6.8 μM for mTRESK) and TASK-1. A2793 may be considered as a tool to discriminate between the resting and activated channels in heterologous expression systems, and to block TRESK activated by calcineurin in the native cells, which do not express TASK-1.
KEYWORDS: A2793 | supplier | TRESK/TASK-1 inhibitor | A 2793 | A-2793 | CAS [88349-90-0] | Potassium | TRESK | TASK-1 | Inhibitor | Ion Channels | Migraine | Neuropathic pain | K2P18.1
| M Lengyel et al. Chemically Modified Derivatives of the Activator Compound Cloxyquin Exert Inhibitory Effect on TRESK (K2P18.1) Background Potassium Channel. Mol Pharmacol. 2019 Jun;95(6):652-660. |
- Certificate of Analysis
- Material Safety Data Sheet
Chemical name
Ethyl 2-(5-chloroquinolin-8-yloxy)acetate
Parent CAS No.
[88349-90-0]
Axon Medchem的业务之一，是独有的Axon Ligands配体库，在世界范围内，被认为是药物研发的标准。这其中，针对850余种生物靶标（包括细胞信号、基因转录、凋亡、细胞周期调控、CNS等），Axon Medchem拥有多达2000余种小分子抑制剂或调节剂。除了配体库，Axon Medchem还是欧洲著名的CRO公司，主要针对生物活性分子和药物类似分子展开合成及协议开发工作，在过去的10年中，Axon Medchem已经发现了多种潜在药物分子，并在生物医药界享有一定的声誉。
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