AS 1842856
Axon 2839
CAS [836620-48-5]
MF C18H22FN3O3MW 347.38
- Purity:99%
- Soluble in DMSO
Description
AS 1842856 is an orally active, potent and selective inhibitor of Forkhead box protein O1 transcription factor (IC50 value of 33 nM). AS 1842856 reduces glucose production through the inhibition of glucose-6 phosphatase and phosphoenolpyruvate carboxykinase mRNA levels in a rat hepatic cell line. Therapeutic drug for treating type 2 diabetes.
KEYWORDS: AS 1842856 | supplier | FOXO1 inhibitor | AS1842856 | AS-1842856 | CAS [836620-48-5] | DNA-RNA | FOXO1 | Inhibitor | Transcription Factors | Diabetes | Forkhead box protein O1 transcription factor
| T Nagashima et al. Discovery of novel forkhead box O1 inhibitors for treating type 2 diabetes: improvement of fasting glycemia in diabetic db/db mice. Mol Pharmacol. 2010 Nov;78(5):961-70. |
- Certificate of Analysis
- Material Safety Data Sheet
Chemical name
5-Amino-7-(cyclohexylamino)-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
Parent CAS No.
[836620-48-5]
Axon Medchem的业务之一，是独有的Axon Ligands配体库，在世界范围内，被认为是药物研发的标准。这其中，针对850余种生物靶标（包括细胞信号、基因转录、凋亡、细胞周期调控、CNS等），Axon Medchem拥有多达2000余种小分子抑制剂或调节剂。除了配体库，Axon Medchem还是欧洲著名的CRO公司，主要针对生物活性分子和药物类似分子展开合成及协议开发工作，在过去的10年中，Axon Medchem已经发现了多种潜在药物分子，并在生物医药界享有一定的声誉。
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