Fatostatin hydrobromide - Fatostatin A hydrobromide | 125B11 hydrobromide
Axon 2975
CAS [298197-04-3]
MF C18H18N2S.HBrMW 375.33
- Purity:99%
- Soluble in DMSO
Description
Fatostatin hydrobromide is a specific inhibitor of SREBP cleavage-activating protein (SCAP), which is required for SREBP activation. Fatostatin hydrobromide possesses antitumor properties including the inhibition of cancer cell proliferation, invasion, and migration, and it arrests cancer cells in G2/M phase. Fatostatin hydrobromide also inhibits tubulin polymerization, which perturbs mitotic spindle assembly and leads to mitotic catastrophe. Fatostatin hydrobromide has anticancer properties in cell culture and in vivo mouse models of prostate and brain cancers.
KEYWORDS: Fatostatin hydrobromide | supplier | SCAP inhibitor | Fatostatin A hydrobromide | 125B11 hydrobromide | CAS [298197-04-3] | [125256-00-0] | DNA-RNA | SREBP | Inhibitor | Transcription Factors
| Y Choi et al. Identification of bioactive molecules by adipogenesis profiling of organic compounds. J Biol Chem. 2003 Feb 28;278(9):7320-4. |
| AA Gholkar et al. Fatostatin Inhibits Cancer Cell Proliferation by Affecting Mitotic Microtubule Spindle Assembly and Cell Division. J Biol Chem. 2016 Aug 12;291(33):17001-8. |
- Certificate of Analysis
- Material Safety Data Sheet
Chemical name
2-(2-Propylpyridin-4-yl)-4-p-tolylthiazole hydrobromide
Parent CAS No.
[125256-00-0]
Axon Medchem的业务之一，是独有的Axon Ligands配体库，在世界范围内，被认为是药物研发的标准。这其中，针对850余种生物靶标（包括细胞信号、基因转录、凋亡、细胞周期调控、CNS等），Axon Medchem拥有多达2000余种小分子抑制剂或调节剂。除了配体库，Axon Medchem还是欧洲著名的CRO公司，主要针对生物活性分子和药物类似分子展开合成及协议开发工作，在过去的10年中，Axon Medchem已经发现了多种潜在药物分子，并在生物医药界享有一定的声誉。
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