ARN 272
Axon 2941
CAS [488793-85-7]
MF C27H20N4O2MW 432.47
- Purity:98%
- Soluble in DMSO
Description
ARN 272 is a selective competitive antagonist of the interaction of anandamide with FAAH-like anandamide transporter (IC50 value of 1.8 µM). Moreover, ARN 272 prevents anandamide internalization in vitro, interrupts anandamide deactivation in vivo, and exerts profound analgesic effects in rodent models of nociceptive and inflammatory pain, which are mediated by CB1 cannabinoid receptors.
KEYWORDS: ARN 272 | supplier | FLAT inhibitor | ARN272 | ARN-272 | CAS [488793-85-7] | Fatty acid (Amides) | FLAT | Inhibitor | Proteins | FAAH-1
| J Fu et al. A catalytically silent FAAH-1 variant drives anandamide transport in neurons. Nat Neurosci. 2011 Nov 20;15(1):64-9. |
- Certificate of Analysis
- Material Safety Data Sheet
Chemical name
4-(4-(4-Hydroxyphenyl)phthalazin-1-ylamino)-N-phenylbenzamide
Parent CAS No.
[488793-85-7]
Axon Medchem的业务之一，是独有的Axon Ligands配体库，在世界范围内，被认为是药物研发的标准。这其中，针对850余种生物靶标（包括细胞信号、基因转录、凋亡、细胞周期调控、CNS等），Axon Medchem拥有多达2000余种小分子抑制剂或调节剂。除了配体库，Axon Medchem还是欧洲著名的CRO公司，主要针对生物活性分子和药物类似分子展开合成及协议开发工作，在过去的10年中，Axon Medchem已经发现了多种潜在药物分子，并在生物医药界享有一定的声誉。
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