BAY-876
Axon 2660
CAS [1799753-63-1]
MF C24H16F4N6O2MW 496.42
- Purity:99%
- Soluble in DMSO
Description
BAY-876 is a higly selective GLUT1 inhibitor (IC50 value 2 nM). In vitro PK data showed that BAY-876 was very stable in liver microsomes and hepatocytes; preliminary in vivo PK studies demonstrated a good oral bioavailability and long terminal half-life.
KEYWORDS: BAY-876 | supplier | GLUT1 inhibitor | BAY876 | BAY 876 | CAS [1799753-63-1] | Glucose | GLUT1 | Inhibitor | Proteins | Transporter | Glucose Transporter 1
| H Siebeneicher et al. Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876. ChemMedChem. 2016 Oct 19;11(20):2261-2271. |
- Certificate of Analysis
- Material Safety Data Sheet
Chemical name
N4-(1-(4-Cyanobenzyl)-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-7-fluoroquinoline-2,4-dicarboxamide
Parent CAS No.
[1799753-63-1]
Axon Medchem的业务之一，是独有的Axon Ligands配体库，在世界范围内，被认为是药物研发的标准。这其中，针对850余种生物靶标（包括细胞信号、基因转录、凋亡、细胞周期调控、CNS等），Axon Medchem拥有多达2000余种小分子抑制剂或调节剂。除了配体库，Axon Medchem还是欧洲著名的CRO公司，主要针对生物活性分子和药物类似分子展开合成及协议开发工作，在过去的10年中，Axon Medchem已经发现了多种潜在药物分子，并在生物医药界享有一定的声誉。
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