AGI 6780

Based on 8 reference(s) in Google Scholar9108

Axon 2274

CAS [1432660-47-3]

MF C21H18F3N3O3S2MW 481.51

Purity:99%
Soluble in DMSO

AGI 6780

Description

Inhibitor of isocitrate dehydrogenases (IDH) selective for mutant IDH2.AGI 6780 potently and selectively inhibits the tumor-associated mutant IDH2/R140Q (EC50 value <20 nm="" for="" reduction="" of="" 2hg="" levels="" in="" cell="" lines)="" in="" an="" allosteric="" manner="" at="" the="" dimer="" interface,="" and="" induces="" differentiation="" of="" tf-1="" erythroleukemia="" and="" primary="" human="" acute="" myelogenous="" leukemia="" cells="" in="" vitro.="">

References
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Extra info

F. Wang et al. Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation. Science. 2013, 340, 622-626.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & OncologyDiabetes & MetabolismEpigeneticsEC 1.1.1.42Stem Cell DifferentiatorIDH

Potent and selective inhibitor of the tumor-associated mutant IDH2 (R140Q)

Chemical name

N-cyclopropyl-4-(thiophen-3-yl)-3-(3-(3-(trifluoromethyl)phenyl)ureido)benzenesulfonamide

Parent CAS No.

[1432660-47-3]

品牌介绍

Axon Medchem的业务之一，是独有的Axon Ligands配体库，在世界范围内，被认为是药物研发的标准。这其中，针对850余种生物靶标（包括细胞信号、基因转录、凋亡、细胞周期调控、CNS等），Axon Medchem拥有多达2000余种小分子抑制剂或调节剂。除了配体库，Axon Medchem还是欧洲著名的CRO公司，主要针对生物活性分子和药物类似分子展开合成及协议开发工作，在过去的10年中，Axon Medchem已经发现了多种潜在药物分子，并在生物医药界享有一定的声誉。

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