AMD 3100 - Plerixafor | SID 791 | JM 3100

Based on 15 reference(s) in Google Scholar81015

Axon 1738

CAS [155148-31-5]

MF C28H54N8.8HClMW 794.47

Purity:100%
Soluble in water

AMD 3100

Description

Highly potent and selective chemokine CXCR4 receptor antagonist, with IC50 values to be 0.02-0.13 and >25 μM for CXCR4 and all other chemokine receptors respectively); HIV inhibitor; an immunostimulant used to multiply hematopoietic stem cells in cancer patients

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E De Clercq et al. Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100. Antimicrob. agents chemother. 1994, 38(4), 668–74.

SL Davies et al. Plerixafor Hydrochloride. Drugs Fut. 2007,32(2), 123.

AF Cashen et al. AMD3100: CXCR4 antagonist and rapid stem cell-mobilizing agent. Future Oncol. 2007, 3(1), 19–27.

G Calandra et al. AMD3100 plus G-CSF can successfully mobilize CD34+ cells from non-Hodgkin"s lymphoma, Hodgkin"s disease and multiple myeloma patients previously failing mobilization with chemotherapy (...). Bone Marrow Transpl. 2008, 41, 331–338.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & OncologyImmunologyStem CellImmunomodulatorA2Chemokine

CXCR4 antagonist

Chemical name

1,4-bis((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzene octahydrochloride

Parent CAS No.

[110078-46-1]

品牌介绍

Axon Medchem的业务之一，是独有的Axon Ligands配体库，在世界范围内，被认为是药物研发的标准。这其中，针对850余种生物靶标（包括细胞信号、基因转录、凋亡、细胞周期调控、CNS等），Axon Medchem拥有多达2000余种小分子抑制剂或调节剂。除了配体库，Axon Medchem还是欧洲著名的CRO公司，主要针对生物活性分子和药物类似分子展开合成及协议开发工作，在过去的10年中，Axon Medchem已经发现了多种潜在药物分子，并在生物医药界享有一定的声誉。

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